A Facile Synthesis of 2-Amino-5-Cyano-4, 6-Disubstitutedpyrimidines under MWI
نویسندگان
چکیده
منابع مشابه
Triphenylphosphine Catalysed Facile Multicomponent Synthesis of 2-Amino-3-Cyano-6-Methyl-4-Aryl-4H-Pyrans
Triphenyl phosphine(PPh3), an efficient and reusable catalyst, catalysed the synthesis of 2-amino-3-cyano-6-methyl-4-aryl-4H-pyran-5-ethylcarboxylate derivatives by one-pot condensation of aromatic aldehydes, malononitrile and ethyl acetoacetate in EtOH-H2O (1:1) at reflux conditions. The results show that ...
متن کاملtriphenylphosphine catalysed facile multicomponent synthesis of 2-amino-3-cyano-6-methyl-4-aryl-4h-pyrans
triphenyl phosphine(pph3), an efficient and reusable catalyst, catalysed the synthesis of 2-amino-3-cyano-6-methyl-4-aryl-4h-pyran-5-ethylcarboxylate derivatives by one-pot condensation of aromatic aldehydes, malononitrile and ethyl acetoacetate in etoh-h2o (1:1) at reflux conditions. the results show that aromatic aldehydes containing electron-donating groups or electron-withdrawing groups cou...
متن کاملOne Step Synthesis of 6-Amino-5-Cyano-4-Phenyl-2-Mercapto Pyrimidine Using Phosphorus Pentoxide
A simple and efficient approach towards one step synthesis of 6-amino-5-cyano-4-phenyl-2-mercapto pyrimidine and its hydroxyl derivatives have been developed by three component condensation of aromatic aldehydes, malononitrile and thiourea/urea in presence of phosphorus pentoxide (Scheme 1).
متن کاملtert-Butyl 6-amino-5-cyano-2-(2-methoxyethyl)nicotinate
The title compound, C(14)H(19)N(3)O(3), was synthesized by the reaction of 3-meth-oxy-propionitrile, tert-butyl bromo-acetate and eth-oxy-methyl-enemalononitrile. In the crystal, N-H⋯O hydrogen bonds link the mol-ecules into chains propagating along the b axis.
متن کاملCrystal structure of N-[4-amino-5-cyano-6-(methylsulfanyl)pyridin-2-yl]-2-(cyclohexylsulfanyl)acetamide
In the title mol-ecule, C15H20N4OS2, the acetamido fragment is nearly coplanar with the pyridyl ring [C-N-C-C torsion angle = -4.1 (2)°], while the cyclo-hexyl-sulfanyl portion protrudes from this plane [N-C-C-S torsion angle = -40.8 (6)°]. In the crystal, alternating pairwise N-H⋯O and N-H⋯N hydrogen bonds across inversion centres form chains along [101], which are associated into stepped laye...
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ژورنال
عنوان ژورنال: International Journal of Organic Chemistry
سال: 2011
ISSN: 2161-4687,2161-4695
DOI: 10.4236/ijoc.2011.12009